“We found that THC at low doses reduced stress, while higher doses had the opposite effect, underscoring the importance of dose when it comes to THC and its effects.”Ĭhilds and her colleagues recruited 42 healthy volunteers 18 to 40 years old who had some experience with cannabis use but who were not daily users. While it is common knowledge that many people use cannabis for its stress-relieving effects, “very few published studies have looked into the effects of THC on stress, or at the effects of different levels of THC on stress,” says Emma Childs, associate professor of psychiatry in the UIC College of Medicine and corresponding author on the study, published in the journal Drug and Alcohol Dependence. Now, researchers at the University of Illinois at Chicago and the University of Chicago report that low levels tetrahydrocannabinol, or THC, the main psychoactive compound in marijuana, does reduce stress, but in a highly dose-dependent manner: very low doses lessened the jitters of a public-speaking task, while slightly higher doses - enough to produce a mild “high” - actually increased anxiety.Ĭannabis is a highly regulated category 1 substance, and permits to study the drug are difficult to obtain.
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